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KMID : 0914820090090010026
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Journal of the Korean Gastric Cancer Association
2009 Volume.9 No. 1 p.26 ~ p.30
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The Prognostic Value of the Preoperative Lymphocyte Count in Patients with Gastric Cancer
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Kang Shin-Yong
Yu Wan-Sik
Chung Ho-Young
Park Seong-Hoon
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Abstract
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Purpose: The aim of this study was to evaluate the prognostic value of the peripheral blood lymphocyte count before surgery in those patients with gastric cancer.
Materials and Methods: The study group was comprised of a series of 1,054 patients who underwent curative gastrectomy. The appropriate lymphocyte count cutoff value was determined. The prognostic factors were evaluated by univariate and multivariate analyses.
Results: The lymphocyte count cutoff value was 1,500/ul. The patients were classified into two groups: Group A had a lymphocyte count ≥1,500/ul (n=765) and Group B had a lymphocyte count ＜1,500/ul (n=289). There were statistically significant differences between the groups according to their age (P＜0.001), the tumor stage (P=0.038) and the tumor size (P＜0.001). The 5- and 10-year survival rates of Group A were 80.1% and 76.6%, respectively and those of Group B were 72.4% and 63.5%, respectively (P=0.002). When multivariate analysis was performed by the Cox proportional hazards model, the lymphocyte count was not an independent prognostic factor.
Conclusion: Although the prognosis of patients with a high lymphocyte count was better than that of the patients with a low lymphocyte count, our results did not support using the preoperative peripheral blood lymphocyte count as an independent prognostic factor for patients with gastric cancer.
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KEYWORD
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Gastric cancer, Lymphocyte count, Prognosis
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